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Physical dependence is the major limiting factor against long-term use of alprazolam and other benzodiazepines.
Factors which determine the severity of the benzodiazepine withdrawal syndrome experienced during dose reduction of alprazolam include:[14]
dosage
length of use
frequency of dosing
method of withdrawal[15]
personality characteristics of the individual
previous use of cross dependent/cross tolerant drugs (alcohol or other sedative hypnotic drugs)
current use of cross dependent/cross tolerant drugs (alcohol or other sedative hypnotic drugs)
Use of short-acting high potency benzodiazepines for example alprazolam or lorazepam
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